Would a T.C. Nova sound good...

[Bryan]

run through a rack power amp into a cab?

Just wondering...

I'm wanting to simplify my system and I thought this combination might sound good.

[surfreak]

NO.

It is a multieffect only, with no "true" preamp section. To drive a power amp with decent tonal results you need a preamp, whether a real one or a box with a selection of digitally modelled preamps like the Pod.